Osimertinib (AZD9291) 25cm

Osimertinib (AZD9291) 25cmOsimertinib (AZD9291) is an oral, irreversible, and mutant selective EGFR inhibitor with IC50 of 12. 92, 11. 44 and 493. 8 nM for Exon 19 deletion EGFR, L858R T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.

R2 series balance represents a new standard of precision balance

and binds p38

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM

25 nM in p53

Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia

is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity

no inhibition to c-Met and Chk2

Squalane is a naturally occuring lipid in both plants and animals

Bifonazole is a substituted imidazole antifungal agent

Corning PLT

and a panel of anti-targets

6-Chloropurine is used in the preparation of 9-alkylpurines through alkylation with various substituted alkyl halides in dimethyl sulfoxide